Anti-CD45 / LCA Antibody (Clone 135-4C5)

Anti-CD45 / LCA Antibody (Clone 135-4C5)is available at Gentaur for Next week Delivery.

Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphotyrosine phosphatase. This mAb reacts with all isoforms of CD45R expressed by all hematopoietic cells, except erythrocytes, having a higher level of expression on lymphocytes than on granulocytes. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Immunogen Sequence:Stimulated human leukocytes

Target Alternative Name:B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Species Reactivities:Human

Tag Line:Monoclonal Antibody to detect CD45 / LCA in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC

Positive Control:IHC: human Tonsil

Application And Usages:FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT

Handling:The antibody solution should be gently mixed before use