Anti-CD40L (Ruplizumab), Human IgG1 Antibody

Anti-CD40L (Ruplizumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531 ± 155 hours.

Immunogen Sequence:Human CD40L

Target Alternative Name:CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect CD40L in human samples.

Formulation:Supplied in PBS, pH 7.5

Purification: SOURCE: CHO cells

Application:Block; FC

Positive Control:N/A

Application And Usages:/

Handling:The antibody solution should be gently mixed before use