Anti-CD20 (Obinutuzumab), Humanized Antibody

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SKU:
A2180-100
$450
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Description

Anti-CD20 (Obinutuzumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is Type II humanized monoclonal antibody that targets CD20 expressed on pre- and mature B lymphocyte cells. The antibody is glycoengineered to increase the binding of CD 64 and CD16 by 7-10 folds and improve antibody-dependent cellular cytotoxicity (ADCC). Additionally, the glycoengineered structure of the antibody helps recruit immune effector cells such as polymorphonuclear neutrophils (PMNs), which when activated, release inflammatory mediators, and promote phagocytosis. A previous study demonstrated that the binding of the antibody to CD20 causes rearrangement of the actin cytoskeleton, which causes the lysosomal compartment to expand. As a result, the lysosomal membrane becomes permeable, causing Cathepsin B to leak into the cytosol. Excessive leakage of Cathepsin B promotes cell death by necrosis. The original drug has been approved by the FDA to treat patients with chronic lymphocytic leukemia (CLL) in combination with Chlorambucil.

Immunogen Sequence:Human CD20

Target Alternative Name:GA-101, GA101, R7159, RG7159, RO5072759, B1, S7, Bp35, CVID5, MS4A2, MS4A1, LEU-16

Species Reactivities:Human

Tag Line:The biosimilar is a type II humanized monoclonal antibody that targets CD20 and induces B-cell lysis via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:In vitro studies

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
CD20
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
IgG1, kappa
Accession Number:
DB08935
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
FAUX
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
FAUX
ELISA Verified:
FAUX
ChIP Verified:
FAUX
Dot Blot Verified:
FAUX
Flow Cytometry Verified:
FAUX
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