Anti-CD146 Rabbit Monoclonal Antibody

Anti-CD146 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: The CD146 antigen, also known as MCAM, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. CD146 is expressed predominantly on metastatic lesions and advanced primary tumors, and has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas.

Immunogen Sequence:A synthetic peptide corresponding to the residues near C-terminus of human CD146

Target Alternative Name:MCAM; MUC18; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen

Species Reactivities:Human

Tag Line:Rabbit monoclonal antibody to detect CD146 in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified using protein A

Application:IHC, WB

Positive Control:WB: A375 cell lysate; IHC: human breast cancer tissue

Application And Usages:IHC: 1:200 -1:500 dilution; WB: 1:1000 - 1:2000 dilution.

Handling:The antibody solution should be gently mixed before use.