Anti-CD11c Antibody (ITGAX/1243)

Anti-CD11c Antibody (ITGAX/1243)is available at Gentaur for Next week Delivery.

Description: Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.

Immunogen Sequence:Recombinant human ITGAX protein fragment (aa 637-827)

Target Alternative Name:CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95

Species Reactivities:Human

Tag Line:Monoclonal Antibody to detect CD11c in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC

Positive Control:IHC: human Prostate Carcinoma, human Lung Carcinoma, human Follicular Lymphoma

Application And Usages:FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 1-2 ug/ml

Handling:The antibody solution should be gently mixed before use