Anti-Catenin, beta Antibody (CTNNB1/1507)

Anti-Catenin, beta Antibody (CTNNB1/1507)is available at Gentaur for Next week Delivery.

Description: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Immunogen Sequence:Recombinant human full-length beta-Catenin (p120) protein fragment

Target Alternative Name:Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1

Species Reactivities:Human, mouse, rat

Tag Line:Monoclonal Antibody to detect Catenin, beta in human, mouse and rat samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC, WB

Positive Control:IHC: human Tonsil, human Pancreas, Mouse Colon, Rat Colon

Application And Usages:FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, WB: 0.5-1ug/ml, IHC: 1-2 ug/ml

Handling:The antibody solution should be gently mixed before use