Anti-BRCA1 Antibody (BRCA1/1398)

Anti-BRCA1 Antibody (BRCA1/1398)is available at Gentaur for Next week Delivery.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Immunogen Sequence:Recombinant human BRCA1 protein fragment (aa445-620)

Target Alternative Name:BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect BRCA1 in human samples.

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC

Positive Control:IHC: human Breast Carcinoma

Application And Usages:FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, IHC: 5-10 ug/ml

Handling:The antibody solution should be gently mixed before use.