Anti-BRAF V600E Rabbit Monoclonal Antibody

Anti-BRAF V600E Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Serine/threonine-protein kinase B-raf (BRAF) is a member of the Raf family. BRAF mutations are frequent in benign and malignant human tumors. BRAF V600E mutation accounts for the vast majority of BRAF alterations and the mutation induces a conformational change of the activation segment leading to a constitutive kinase activity of BRAF and consecutive phosphorylation of downstream targets. BRAF V600E mutation have been detected in melanoma, papillary thyroid carcinoma, pleomorphic xanthoastrocytomas, Langerhans cell histiocytosis, borderline ovarian cancer, ganglioglioma, colorectal carcinoma, and pilocytic astrocytoma.

Immunogen Sequence:A peptide corresponding to BRAF V600E mutant

Target Alternative Name:N/A

Species Reactivities:Human

Tag Line:Rabbit monoclonal antibody to detect BRAF V600E in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified using protein A

Application:IHC, WB

Positive Control:WB: lysate from cell line expressing V600; IHC: melanoma tissue; ELISA: 293T cells overxpressing BRAF V600

Application And Usages:IHC, ICC: 2 – 10 µg/mL; ELISA: 0.5 – 2 µg/mL; WB: 0.5 – 2 µg/mL.

Handling:The antibody solution should be gently mixed before use.