Anti-Beta-2 Microglobulin Antibody (B2M/961)

Anti-Beta-2 Microglobulin Antibody (B2M/961)is available at Gentaur for Next week Delivery.

Description: Recognizes a protein of 12 kDa, identified as β-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.

Immunogen Sequence:Full length recombinant human B2M protein

Target Alternative Name:B2M, Beta 2 microglobin, Beta 2 microglobulin, Beta chain of MHC class I molecules, Beta-2-microglobulin form pI 5.3, Hdcma22p

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect Beta-2 Microglobulin in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, IHC

Positive Control:IHC: Human cervical carcinoma, Human melanoma, Human endometrial carcinoma, Human bladder carcinoma, Human colon carcinoma, Human renal carcinoma

Application And Usages:FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 0.5-1 ug/ml

Handling:The antibody solution should be gently mixed before use.