Anti-ALK Antibody (ALK/1503)

Anti-ALK Antibody (ALK/1503)is available at Gentaur for Next week Delivery.

Description: The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene, NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serve as an internal positive control.

Immunogen Sequence:Recombinant human ALK protein fragment (aa1360-1460)

Target Alternative Name:ALK Tyrosine Kinase Receptor, ALK/NPM1 fusion gene, Anaplastic lymphoma kinase Ki1, Anaplastic Lymphoma Kinase p80, anaplastic lymphoma receptor tyrosine kinase, CD246, mutant anaplastic lymphoma kinase, NBLST3, Tcrz, TFG/ALK

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect ALK in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, WB

Positive Control:WB: Recombinant Protein, HepG2 Cell lysate

Application And Usages:FC: 0.5-1 ug/1X106 cells in 0.1 ml, IF: 0.5-1 ug/ml, WB: 0.5-1 ug/ml

Handling:The antibody solution should be gently mixed before use.