ALDH2 Antibody (Clone # 138CT22.3.8)

ALDH2 Antibody (Clone # 138CT22.3.8)is available at Gentaur for Next week Delivery.

Description: ALDH2 (Aldehyde dehydrogenase 2 family) belongs to the aldehyde dehydrogenase family which catalyze the chemical transformation from acetaldehyde to acetic acid and is the second enzyme of the major oxidative pathway of alcohol metabolism. Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.

Immunogen Sequence:This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.

Target Alternative Name:ALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI.

Species Reactivities:Human.

Tag Line:Monoclonal Antibody to detect ALDH2 in human samples

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Application:Western blot, IHC, FACS, IF.

Positive Control:Western blot: HepG2 cell lysates, IHC: human brain tissue, FACS: HepG2 cells, IF: HepG2 cells.

Application And Usages:Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10-1:50, IF: ~1:10-1:50.

Handling:The antibody solution should be gently mixed before use.