AGT Antibody (CT)

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SKU:
6708-100
€245
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Description

AGT Antibody (CT)is available at Gentaur for Next week Delivery.

Description: Angiotensinogen, also known as AGT and SERPINA8, is a member of the serpin family. It is anα-2-globulinthat is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. It is expressed by the liver and secreted in plasma. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD).

Immunogen Sequence:This AGT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-450 amino acids from the C-terminal region of human AGT.

Target Alternative Name:AGT; SERPINA8; Angiotensinogen; Serpin A8; Angiotensin-1; Angiotensin I; Angiotensin-2; Angiotensin II; Angiotensin-3; Angiotensin III;

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect AGT in human samples

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Application:Western blot, IHC

Positive Control:Western blot: HepG2 cell lysate, IHC: human hepatocarcinoma tissue

Application And Usages:Western blot: ~1:1000, IHC: ~1:10-1:50

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 μl
Antibody Target:
AGT
Category:
AGT
Lot Number:
9C116708
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
P01019
Gene Id:
AGT
Concentration:
N/A
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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