Acetyl-Lysine Monoclonal Antibody

Acetyl-Lysine Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of lysine involves acetylation. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Protein post-translational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases, and HDACs have become promising targets for anti-cancer drμgs currently in development.

Immunogen Sequence:/

Target Alternative Name:Acetyl Lysine

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect acetyl lysine in human samples.

Formulation:100 ug (0.2 mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.

Purification: Affinity purified mouse IgG using protein G

Application:WB

Positive Control:N/A

Application And Usages:Western blot

Handling:The antibody solution should be gently mixed before use.