TRAIL, murine recombinant

TRAIL, murine recombinant is available at Gentaur for Next week delivery.

Activates rapid apoptosis in tumor cells

Biomolecule/Target: TRAIL

Alternates names: TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2

Synonyms: TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2

Background Information: TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: TRAIL

Gene ID: 22035

NCBI Accession: P50592