Survivin, human recombinant

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SKU:
4160-50
€185
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Description

Survivin, human recombinant is available at Gentaur for Next week delivery.

An inhibitor of caspase activation/apoptosis

Biomolecule/Target: Survivin

Alternates names: Survivin, BIRC5; API4; EPR-1, Apoptosis inhibitor 4, Apoptosis inhibitor survivin

Synonyms: BIRC5; API4; EPR-1

Background Information: Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumour growth. Survivin is highly expressed in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for studying cancer therapy.

Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in PBS.

NCBI Gene Symbol: BIRC5

Gene ID: 332

NCBI Accession: O15392

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Additional Information

Size:
50 μg
Adwords:
Yes-SG
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
18.6 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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