Sirtuin 2, human recombinant

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SKU:
7632-20
€185
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Description

Sirtuin 2, human recombinant is available at Gentaur for Next week delivery.

A NAD-dependent deacetylase

Biomolecule/Target:

Alternates names: NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2

Synonyms: Regulatory protein SIR2 homolog 2, SIR2-like protein 2

Background Information: Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A.

Reconstitution Instructions: N/A

NCBI Gene Symbol: SIRT2

Gene ID: 22933

NCBI Accession: Q8IXJ6

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Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
≥ 80 units/mg
Biological activity:
Activity of SIRT2 was tested using the substrate Arg-His-Lys-Lys(Ac)-AFC, which is a fluorogenic, acetylated peptide based on residues 379-382 of p53.
Results:
N/A
Molecular Weight:
43 kDa
Storage Temperature:
-70°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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