sCD22, Human Recombinant

sCD22, Human Recombinant is available at Gentaur for Next week delivery.

Plays a potential role in limiting antigen receptor signaling

Biomolecule/Target: sCD22

Alternates names: Leu-14, B-Lymphocyte cell adhesion molecule, BL-CAM, Siglec-2

Synonyms: Leu-14, B-Lymphocyte cell adhesion molecule, BL-CAM, Siglec-2

Background Information: CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand. Recombinant human CD22 is a soluble 75.0 kDa protein which corresponds to the extracellular domain of CD22.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: CD22

Gene ID: 933

NCBI Accession: P20273