Phosphogluconate dehydrogenase, human recombinant

Phosphogluconate dehydrogenase, human recombinant is available at Gentaur for Next week delivery.

An enzyme involved in the pentose phosphate shunt, major source of NADPH.

Biomolecule/Target: PGD

Alternates names: 6PGD, PGD

Synonyms: 6PGD, PGD

Background Information: PGD (Phosphogluconate dehydrogenase), also known as 6PGD, is a 483 amino acid enzyme that is involved in the pentose phosphate shunt. Pentose is required for nucleic acid biosynthesis and the pentose phosphate cycle is a major source of NADPH. PGD deficiency increases the level of erythrocyte pyruvate kinase (PK) activity and reduces glutathione synthetase (GSH), resulting in hemolysis. Defects in PGD are generally asymptomatic and are inherited in an autosomal dominant fashion. Recombinant human PGD protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques

Reconstitution Instructions: N/A

NCBI Gene Symbol: PGD

Gene ID: 5226

NCBI Accession: P52209