Nanog, human recombinant

Nanog, human recombinant is available at Gentaur for Next week delivery.

A regulatory protein associated with undifferentiated pluripotent cells

Biomolecule/Target: Nanog

Alternates names: Homeobox transcription factor Nanog

Synonyms: Homeobox transcription factor Nanog

Background Information: Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of Nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of Nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, which maintains pluripotency and self-renewal via a STAT3 independent pathway. Recombinant human Nanog is a 34.7 kDa protein, which is synthesized as a 304 amino acid polypeptide lacking a signal sequence for secretion.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: Nanog

Gene ID: 79923

NCBI Accession: Q9H9S0