Human Recombinant Ubiquitin-K27

Human Recombinant Ubiquitin-K27 is available at Gentaur for Next week delivery.

Serves as a substrate for K27 polyubiquitination

Biomolecule/Target:

Alternates names:

Synonyms: Human Recombinant Ubiquitin-K27

Background Information: Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have all available lysines mutated to arginines, except at position 27. This molecule, therefore, can only form polyubiquitin chains of K27 linkage type. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

Reconstitution Instructions: N/A

NCBI Gene Symbol: RPS27A

Gene ID: 6233

NCBI Accession: P62979