Human Recombinant FKBP1a/FKBP12

Human Recombinant FKBP1a/FKBP12 is available at Gentaur for Next week delivery.

An immunophilin family protein functioning as a protein folding chaperone

Biomolecule/Target:

Alternates names: FK506 binding protein 1a, 12kDa, PPIase FKBP1A, Rotamase, FKBP1, PKC12

Synonyms: Human Recombinant FKBP1a/FKBP12

Background Information: FKBP1A is part of the family of immunophilins, which have in common high affinity for immunosuppressant drugs and a peptidyl-prolyl cis-trans isomerase (PPIase). In the absence of immunosuppressive ligands, FKBP1A is involved in intracellular calcium regulation by associating with 3 types of Ca2+ release channel complexes: skeletal ryanodine receptors, cardiac ryanodine receptors and the inositol 1, 4, 5-triphosphate receptor. FKBP1A also interacts with TGF type I receptor exerting an inhibitory effect on the TGFβ-I signaling pathway. FKBP12 plays a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. FKBP1A increase the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Reconstitution Instructions: N/A

NCBI Gene Symbol: FKBP1A

Gene ID: 2280

NCBI Accession: P62942