Human CellExp™ TIGIT, Fc Tag, Mouse Recombinant

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SKU:
P1213-50
€185
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Description

Human CellExp™ TIGIT, Fc Tag, Mouse Recombinant is available at Gentaur for Next week delivery.

>95% Pure, Human cell expressed TIGIT

Biomolecule/Target: Tigit

Alternates names: TIGIT, VSIG9, VSTM3

Synonyms: TIGIT, VSIG9, VSTM3

Background Information: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3), which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Tigit

Gene ID: 100043314

NCBI Accession: A0A0B4J1G6

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
> 95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per/μg
Activity (Specifications/test method):
Measured by its ability to converts 1 μmole of L-methionine and ATP to S-adenosyl-L-methionine (AdoMet), inorganic phosphate (Pi), and pyrophosphate (PPi) at 37ºC and pH 7
Biological activity:
Immobilized Mouse TIGIT, Fc Tag at 5μg/mL (100 μL/well) can bind Human Nectin-2, His Tag with a linear range of 2.5-20 μg/mL.
Results:
N/A
Molecular Weight:
40 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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