Human CellExp™ SARS-CoV-2 Spike Protein (RBD; 331-524), Recombinant

Human CellExp™ SARS-CoV-2 Spike Protein (RBD; 331-524), Recombinant is available at Gentaur for Next week delivery.

Glycoprotein that enables viral entry into the host cell

Biomolecule/Target:

Alternates names: Novel Coronavirus RBD Protein, 2019-nCoV Spike Protein RBD, SARS-CoV-2 S1 RBD Protein

Synonyms: Novel Coronavirus RBD Protein, 2019-nCoV Spike Protein RBD, SARS-CoV-2 S1 RBD Protein

Background Information: The spike (S) glycoprotein of coronaviruses mediates entry into receptor-expressing host cells and plays the most important role in viral attachment, fusion, and entry; therefore, it serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives membrane fusion and eventual entry of the virus. Within the S1 protein, the highly conserved receptor-binding domain (RBD) expresses a high affinity for the Angiotensin converting enzyme 2 receptor (ACE2). Experiments have shown that the RBD fragment blocked S-protein mediated infections and suggests potential as a viral attachment or entry inhibitor against SARS-CoV-2.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: S

Gene ID: 43740568

NCBI Accession: HEK 293 cells