Human CellExp™ OX40 Ligand / TNFSF4, Mouse Recombinant

Human CellExp™ OX40 Ligand / TNFSF4, Mouse Recombinant is available at Gentaur for Next week delivery.

A costimulatory molecule implicated in long-term T-cell immunity, also cts as a receptor for human herpesvirus 6B/HHV-6B

Biomolecule/Target: TNFSF4

Alternates names: OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1

Synonyms: OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1

Background Information: Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Tnfsf4

Gene ID: 22164

NCBI Accession: P43488