Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant

Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant is available at Gentaur for Next week delivery.

A costimulatory molecule implicated in long-term T-cell immunity, also cts as a receptor for human herpesvirus 6B/HHV-6B

Biomolecule/Target: TNFRSF4

Alternates names: OX40L,TNFSF4,CD253

Synonyms: OX40L,TNFSF4,CD252

Background Information: Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

NCBI Gene Symbol: TNFRSF4

Gene ID: 7293

NCBI Accession: NP_003317