Human CellExp™ LAIR1 / CD305, Human Recombinant

Human CellExp™ LAIR1 / CD305, Human Recombinant is available at Gentaur for Next week delivery.

Negative regulator of NK cells, B cells and T cells

Biomolecule/Target: IL7R

Alternates names: LAIR1, CD305

Synonyms: LAIR1, CD305

Background Information: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 µg/ml.

NCBI Gene Symbol: LAIR1

Gene ID: 3903

NCBI Accession: Q6GTX8