Human CellExp™ GFR alpha-like, Human Recombinant

Human CellExp™ GFR alpha-like, Human Recombinant is available at Gentaur for Next week delivery.

Neuronal brainstem receptor mediating the anorectic funtions of GDF15

Biomolecule/Target:

Alternates names: GFR alpha like, GFR alpha-like, GFRAL, GRAL

Synonyms: GFR alpha like, GFR alpha-like, GFRAL, GRAL

Background Information: GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: GFRAL

Gene ID: 389400

NCBI Accession: Q6UXV0