Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant

Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant is available at Gentaur for Next week delivery.

Biomolecule/Target: FZD2

Alternates names: FZD2, Frizzled-2, Fz-2, hFz2, FzE2

Synonyms: FZD2, Frizzled-2, Fz-2, hFz2, FzE2

Background Information: Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.

NCBI Gene Symbol: FZD2

Gene ID: 2535

NCBI Accession: Q14332