Human CellExp™ CD46, Human Recombinant

Human CellExp™ CD46, Human Recombinant is available at Gentaur for Next week delivery.

Has cofactor activity for inactivation of complement components C3b and C4b by serum factor I.

Biomolecule/Target:

Alternates names: CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Synonyms: CD46, AHUS2, MCP, MIC10, TLX, TRA2.10

Background Information: Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2).

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: CD46

Gene ID: 4179

NCBI Accession: P15529