Human CellExp™ CD304 / NRP1 / Neurophilin-1, human recombinant

Human CellExp™ CD304 / NRP1 / Neurophilin-1, human recombinant is available at Gentaur for Next week delivery.

A receptor involved in the development of the cardiovascular system

Biomolecule/Target: CD304/NRP1/Neurophilin-1

Alternates names: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Synonyms: NRP1, Neuropilin-1, NRP, VEGF165R, CD304

Background Information: Neuropilin-1 (NRP1) is also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: NRP1

Gene ID: 8829

NCBI Accession: O14786