EED (1- 441aa), Human recombinant

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SKU:
7667-25
$183
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Description

EED (1- 441aa), Human recombinant is available at Gentaur for Next week delivery.

Repressor of gene activity through histone deacetylation

Biomolecule/Target: EED

Alternates names: Embryonic Ectoderm Development

Synonyms: EED (1- 441aa), Human recombinant

Background Information: Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.

Reconstitution Instructions: N/A

NCBI Gene Symbol: EED

Gene ID: 8726

NCBI Accession: O75530

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Additional Information

Size:
25 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Insect (SF21) cells (baculovirus expression system)
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
53.5 kDa (1- 441 aa + NT His Tag)
Storage Temperature:
-80°C
Shelf Life:
6 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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