Active HIV-2 Protease Recombinant (GST-tagged)

Active HIV-2 Protease Recombinant (GST-tagged) is available at Gentaur for Next week delivery.

≥85% Pure Active Recombinant HIV2 Protease (GST tagged) for inhibitor screening assays, activity studies, selectivity profiling, western blotting, ELISA, and numerous such applications.

Biomolecule/Target: HIV-2 Protease

Alternates names: HIV-2 retropepsin, HIV-2 Protease (PR2), cd05482

Synonyms: HIV-2 retropepsin, HIV-2 Protease (PR2), cd05482

Background Information: HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells. HIV-2 has been found to be less pathogenic than HIV-1. The mechanism of HIV-2 is not clearly defined, nor the difference from HIV-1, however the transmission rate is much lower in HIV-2 than HIV-1.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HIV2 protease

Gene ID: N/A

NCBI Accession: Q9YQ30