Renin Inhibitor Screening Kit (Fluorometric)

Renin Inhibitor Screening Kit (Fluorometric)is available at Gentaur for Next week Delivery.

Sensitive Assay to Screen Renin Inhibitors, HTS.

Description:

Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Renin inhibitors also adaptable to a 384 well format.

Applications:

Sample Typ:e

Alternate Name: Angiotensinogenase Inhibitor Screening Kit (Fluorometric)

Features and Benefits:

• Rapid & simple • Reliable test for screening potential inhibitors of renin • Includes Inhibitor Control [Aliskiren]