Rat Renin Inhibitor Screening Kit (Fluorometric)

Rat Renin Inhibitor Screening Kit (Fluorometric)is available at Gentaur for Next week Delivery.

Sensitive Assay to Screen Rat Renin Inhibitors, HTS.

Description:

Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Rat Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Rat Renin inhibitor, the rate of hydrolysis of the substrate is decreased or inhibited. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of rat renin inhibitors. It is also adaptable to a 384-well format.

Applications: • Screening/Characterizing/studying potential inhibitors of rat renin

Sample Typ:e

Alternate Name:

Features and Benefits:

• Rapid & HTS • Reliable test for screening/studying/characterizing potential inhibitors of rat renin • Includes Inhibitor Control