Description
RAC1 Polyclonal Antibodyis available at Gentaur for next week delivery.
Specificity:
Alternative Names: P63000
Immunogen: Recombinant Human Ras-related C3 botulinum toxin substrate 1 protein (11-185AA)
Technical Notes: For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Application: ELISA, IHC, IF; Recommended dilution: IHC:1:100-1:1200, IF:1:200-1:500
Restriction:
Comments: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
Additional Information
Species Reactivity: |
Human |
Size: |
100ug |
Host: |
Rabbit |
Clonality: |
Polyclonal |
Concentration: |
-20°C |
Storage: |
1 year |
Expiry Date: |
Ice packs |
Shipping Condition: |
Conjugation service and the corresponding secondary antibody are available. |