Phospho-EPS15 (Tyr849) Antibody

Phospho-EPS15 (Tyr849) Antibodyis available at Gentaur for Next week Delivery.

Description: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Immunogen Sequence:A synthesized peptide derived from human EPS15 around the phosphorylation site of Tyrosine 849.

Target Alternative Name:Epidermal growth factor receptor substrate 15, Protein Eps15, Protein AF-1p, EPS15, AF1P

Species Reactivities:Rat, Mouse, Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-EPS15 (Tyr849).

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Purification: Affinity purified

Application:Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.