Phospho-Bad (Ser136) antibody

Phospho-Bad (Ser136) antibodyis available at Gentaur for Next week Delivery.

Description: Bad is a member of the Bcl-2 family protein that selectively dimerize with Bcl-xL and Bcl-2 resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser 136. Phosphorylation at these sites results in the binding of Bad to 14-3-3 proteins and the inhibition of Bad binding to Bcl-xL and Bcl-2. Recently, Akt has also been shown to promote cell survival via its ability to phosphorylate Bad at Ser136.

Immunogen Sequence:Synthesized peptide derived from human Bad around the phosphorylation site of S136

Target Alternative Name:BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect Bad (Phospho-Ser136) in human, mouse and Rat samples

Formulation:100 ug (1 mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity purified rabbit IgG

Application:WB, IHC, ELISA

Positive Control:Western blot

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELI+AJ1521+AI1515:AL1533

Handling:The antibody solution should be gently mixed before use