recMAb™ Anti-ATRX/RAD54 Antibody

recMAb™ Anti-ATRX/RAD54 Antibodyis available at Gentaur for Next week Delivery.

Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen Sequence:Recombinant human ATRX protein

Target Alternative Name:JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX, MRXHF1, SFM1, SHS, ATR2

Species Reactivities:Human

Tag Line:Recombinant rabbit monoclonal antibody to detect the expression of ATRX/RAD54 in human samples

Formulation:In 10 mM PBS

Purification: Protein A/G purified

Application:Immunohistochemistry (IHC)

Positive Control:/

Application And Usages:IHC (1-2 µg/ml)

Handling:The antibody solution should be gently mixed before use.