Phospho-PDGFR beta (Tyr716) polyconal Antibody

Phospho-PDGFR beta (Tyr716) polyconal Antibodyis available at Gentaur for Next week Delivery.

Description: Platelet-derived growth factor (PDGF) refers to a family of disulphide-bonded dimeric isoforms that are important for growth and survival, and which function in several types of connective tissue cell. There are four members of the platelet-derived growth factor (PDGF) family: PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-α and PDGFR-β. PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. Upon limited proteolysis, PDGF-DD is activated and becomes a specific agonistic ligand for PDGFR-β. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines.

Immunogen Sequence:Synthetic peptide

Target Alternative Name:PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect PDGFR beta (Phospho-Tyr716) in human samples.

Formulation:100 ug (1 mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.

Purification: Affinity purified rabbit IgG using protein G

Application:WB, Immunoblot, ELISA

Positive Control:N/A

Application And Usages:Western blot, Immunoblot: 0.5-2 μg/ml, ELISA

Handling:The antibody solution should be gently mixed before use.