Phospho-p53 (Ser376) Antibody

Phospho-p53 (Ser376) Antibodyis available at Gentaur for Next week Delivery.

Description: p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human p53

Target Alternative Name:P53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

Species Reactivities:Human, Mouse

Tag Line:Polyclonal antibody to detect endogenous levels of p53 (pS376) in human and mouse.

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IH

Positive Control:WB: NIH3T3, IHC: human brain tissue

Application And Usages:WB; 1:500 – 1:2000, IHC; 1:50 – 1:200

Handling:The antibody solution should be gently mixed before use