Nitrotyrosine Antibody

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SKU:
5416-50
€265
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Description

Nitrotyrosine Antibodyis available at Gentaur for Next week Delivery.

Description: Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It is a marker for inflammation and nitric oxide (NO) production. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Tyrosine nitration can inactivate enzymes and receptors that depend on tyrosine residues for their activity. Nitration prevents phosphorylation of tyrosine residues important for signal transduction. Nitrotyrosine has been detected in inflammatory processes such as septic shock, rheumatoid arthritis, celiac disease, atherosclerotic plaques, chronic renal failure and keratoconus. Because nitrotyrosine is a stable product of multiple pathways, such as the formation of peroxynitrite, its plasma concentration may be a useful determinant of NO-dependent damage in vivo. Nitrotyrosine Antibody detects proteins and peptides containing nitro-tyrosine in a manner independent of the surrounding amino acid sequence. It is a valuable tool for identifying new nitrated proteins as well as for assaying protein nitration and measuring levels of nitrated proteins in tissues and samples.

Immunogen Sequence:Nitrated keyhole limpet hemocyanin (KLH).

Target Alternative Name:/

Species Reactivities:All species

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Formulation:Supplied as rabbit serum. Does not contain sodium azide

Purification: /

Application:Western blotting , ELISA.

Positive Control:/

Application And Usages:Western blotting 1/500 using alkaline phosphatase and BCIP/NBT, ELISA (Recognizes nitrated BSA 1/1,000,000 in ELISA).

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
50 µl
Antibody Target:
Nitrotyrosine
Category:
Nitrotyrosine
Lot Number:
70916
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Concentration:
Undetermined in neat serum
Appearance:
Provided as rabbit serum
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Not Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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