Menin Antibody

Menin Antibodyis available at Gentaur for Next week Delivery.

Description: Menin (multiple endocrine neoplasia I, MEN1, MEAI, SCG2) is a nuclear tumor suppressor that is mutated in patients with multiple endocrine neoplasia type I (MEN1). Menin can activate the transcription of differentiation-regulating genes by covalent histone modification. In osteoblasts, the interaction of menin and the TGFβ/Smad3 pathway negatively regulates BMP2/Smad1/5- and Runx2-dependent transcription activities leading to inhibition of late-stage differentiation. Menin regulates the expression of IGFBP-2 by influencing the IGFBP-2 promoter. Ectopic overexpression of menin via adenoviruses induces apoptosis in murine embryonic fibroblasts in a Bax/Bak-dependent manner. Two mRNA exist and two variants of the shorter mRNA have alternative splicing that changes the CDS. Five variants where alternative splicing takes place in the 5' UTR have been identified.

Immunogen Sequence:Synthetic peptide of human Menin

Target Alternative Name:MEAI, Multiple Endocrine Adenomatosis 1; ZES, Zollinger-Ellison Syndrome; SCG2, Suppressor Candidate Gene 2

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (1:500 – 1:2000). However, the optimal concentrations should be determined individually. 293T cell lysate can be used as a positive control. The antibody recognizes the Menin of human, mouse, and rat origins. Reactivity to other species has not been tested.

Handling:The antibody solution should be gently mixed before use.