MBD1 polyclonal antibody

MBD1 polyclonal antibodyis available at Gentaur for Next week Delivery.

Description: MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC’s) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription.

Immunogen Sequence:MBD1 (Methyl-CpG-binding domain protein 1) synthetic peptide containing a sequence from the N-terminal conjugated to KLH

Target Alternative Name:CXXC3, PCM1, RFT, Methyl-CpG-Binding Domain 1

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect MBD1 in human samples.

Formulation:In PBS with 0.05% sodium azide and 0.05% ProClin 300.

Purification: Affinity Purified

Application:Western blot, ELISA, ChIP.

Positive Control:Western blot: Hela cells, ELISA: peptides, ChIP: U2OS cells.

Application And Usages:ChIP: 1.5 µg/ChIP, WB: 1:500, ELISA: 1:1000.

Handling:The antibody solution should be gently mixed before use.