LRP-5/6 Antibody

LRP-5/6 Antibodyis available at Gentaur for Next week Delivery.

Description: LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.

Immunogen Sequence:Synthetic peptide surrounding amino acid 437 of human LRP

Target Alternative Name:LRP-5 , LRP -6

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control. The antibody recognizes the ~170 kDa full length LRP-5/6 of human and mouse origins. A cleavage fragment (~120 kDa) can also be detected. Reactivity to other species has not been tested.

Handling:The antibody solution should be gently mixed before use.