LC3 (APG8C) Antibody

LC3 (APG8C) Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.

Immunogen Sequence:This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LC3.

Target Alternative Name:MAP1LC3C; Microtubule-associated proteins 1A/1B light chain 3C; Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; Microtubule-associated protein 1 light chain 3 gamma

Species Reactivities:Human.

Tag Line:Polyclonal antibody to detect LC3 in human samples

Formulation:Supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Ammonium sulphate precipitated and dialyzed Antibody

Application:Western blot, Immunohistochemistry

Positive Control:WB: Hela, HepG2 cells, IHC: human cancer tissue

Application And Usages:WB: ~1:1000, IHC: 1:50-100.

Handling:The antibody solution should be gently mixed before use.