IkBalpha Antibody (Clone 6A055)

IkBalpha Antibody (Clone 6A055)is available at Gentaur for Next week Delivery.

Description: NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/g. External stimuli such TNF-α or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first gene induced following NF-kB activation is IkBα.

Immunogen Sequence:Recombinant human IkBa

Target Alternative Name:IkappaBalpha , MAD3, MAD-3, IKBA, NFKBI, IKB-alpha, I-kappa-B-alpha

Species Reactivities:Human

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Formulation:100 µg (0.25 mg/ml) immunoaffinity purified mouse monoclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunohistochemistry

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml) and immunoprecipitation (1-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects both phosphorylated and non-phosphorylated forms of IkBα.

Handling:The antibody solution should be gently mixed before use.