HdmX/MDM4 Antibody

HdmX/MDM4 Antibodyis available at Gentaur for Next week Delivery.

Description: The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.

Immunogen Sequence:Synthetic peptide of human HmdX/MDM4

Target Alternative Name:HdmX, MdmX, MDM4, homolog of mouse double minute 4 protein

Species Reactivities:Human

Tag Line:/

Formulation:100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation

Positive Control:/

Application And Usages:Western blotting (1:500 – 1:1500) and Immunoprecipitation. MCF7 cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the HdmX/MDM4 of human origin. Reactivity to other species has not been tested.

Handling:The antibody solution should be gently mixed before use.