H4K8ac Antibody

H4K8ac Antibodyis available at Gentaur for Next week Delivery.

Description: Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called “histone code”. Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of histone H4 is associated with active gene transcription.

Immunogen Sequence:KLH-conjugated synthetic peptide of Histone H4 containing the acetylated lysine 8

Target Alternative Name:Histone H4

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect H4K8ac in human samples.

Formulation:In PBS with 0.05% (W/V) sodium azide.

Purification: Whole antiserum from rabbit

Application:Western blot, ELISA, ChIP, Dot blot.

Positive Control:WB: HeLa cells, ELISA: Antigen, ChIP: Human osteosarcoma cells, Dot blot: Histone peptides

Application And Usages:WB: 1:250, ELISA: 1:500, Dot Blot: 1:20,000, ChIP: 5 µl/ChIP.

Handling:The antibody solution should be gently mixed before use.