Glutathione Peroxidase 4 Antibody (Clone 1H11)

Glutathione Peroxidase 4 Antibody (Clone 1H11)is available at Gentaur for Next week Delivery.

Description: Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

Immunogen Sequence:Recombinant human protein purified from E.coli

Target Alternative Name:Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GPX4

Species Reactivities:Human, mouse, rat

Tag Line:Monoclonal antibody to detect Glutathione Peroxidase 4 in human, mouse and rat samples.

Formulation:100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol

Purification: Ammonium sulphate precipitation

Application:IP, ELISA.

Positive Control:WB and IP: HL60 cell lysate

Application And Usages:IP: 1-2 µl, ELISA.

Handling:The antibody solution should be gently mixed before use.