DR4 Antibody

DR4 Antibodyis available at Gentaur for Next week Delivery.

Description: Apoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family throμgh their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4 (death receptor 4) and TRAIL-R1. The ligand for this novel death receptor has been identified and termed TRAIL. DR4 is expressed in most of the human tissues including spleen, peripheral blood leukocytes (PBLs), small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NFkB activation in many tissues and cells.

Immunogen Sequence:Synthetic peptide corresponding to residues surrounding amino acids 454 of human DR4

Target Alternative Name:TNFRSF10A, TRAILR1, mgC9365, APO2, CD261, TRAIL-R1, TRAILR-1

Species Reactivities:Human

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Formulation:30 µg (0.5 mg/ml) affinity purified rabbit anti-DR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects a 57 kDa in samples from human origin. Jurkat cell lysate can be used as a positive control.

Handling:The antibody solution should be gently mixed before use.